Montepulciano d’Abruzzo is a red Italian wine made from the Montepulciano wine grape in the Abruzzo region of east-central Italy^. It should not be confused with Vino Nobile di Montepulciano, a Tuscan wine made from Sangiovese and other grapes.

Montepulciano d’Abruzzo was classified as Denominazione di origine controllata (DOC) in 1968; a separate Denominazione di origine controllata e Garantita (DOCG) for wine produced around Teramo, Montepulciano d’Abruzzo Colline Teramane (Teramo hills), was established in 1995 and promoted in 2003.

In the late 20th and early 21st century, Montepulciano d’Abruzzo earned a reputation as one of the most widely exported DOC wines in Italy. It is typically dry with soft tannins and often consumed young.

In addition to Montepulciano, up to 15% Sangiovese is permitted in the blend. Wines aged by the maker for more than two years may be labeled “Riserva.”